We've traveled from San Diego (north county) many times. With 1 gas and pee stop our typical trip is 5.5 hours. We usually cross at Calexico East. If you can handle the winding Hwy 2 at La Rumorosa, crossing at Tecate and taking Hwy 2 to Hwy 5 to Hwy 4 to Hwy 3 saves a 1/2 hour and 30 miles...